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PTGES3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15185 |
|---|---|
| Clone Names | 100525220 |
| Gene ID | 10728 |
|---|---|
| Other Names | Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, cPGES, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, PTGES3, P23, TEBP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PTGES3 |
|---|---|
| Synonyms | P23, TEBP |
| Function | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q3ZBF7}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes.
References
Chen, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7401-7406(2010)Lee, J.H., et al. Cancer Lett. 290(1):76-86(2010)Chadli, A., et al. J. Biol. Chem. 285(6):4224-4231(2010)Woo, S.H., et al. J. Biol. Chem. 284(45):30871-30880(2009)Mattila, S., et al. Neuropathology 29(2):156-165(2009)
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