MTA3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BTC8 |
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Clone Names | 100528219 |
Gene ID | 57504 |
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Other Names | Metastasis-associated protein MTA3, MTA3, KIAA1266 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MTA3 |
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Synonyms | KIAA1266 |
Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:12705869, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Cytoplasm {ECO:0000250|UniProtKB:Q924K8} |
Tissue Location | Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MTA3 plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels.
References
Bruning, A., et al. Histochem. Cell Biol. 132(1):33-38(2009)Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :Zhang, H., et al. Genes Dev. 20(21):2943-2948(2006)Yu, J.C., et al. J. Biomed. Sci. 13(3):419-432(2006)Fujita, N., et al. Cell 119(1):75-86(2004)
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