PROK2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9HC23 |
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Clone Names | 100318115 |
Gene ID | 60675 |
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Other Names | Prokineticin-2, PK2, Protein Bv8 homolog, PROK2, BV8 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PROK2 |
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Synonyms | BV8 |
Function | May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle. |
Cellular Location | Secreted. |
Tissue Location | Expressed in the testis and, at low levels, in the small intestine |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein expressed in thesuprachiasmatic nucleus (SCN) circadian clock that may function asthe output component of the circadian clock. The secreted form ofthe encoded protein may also serve as a chemoattractant forneuronal precursor cells in the olfactory bulb. Proteins from othervertebrates which are similar to this gene product were isolatedbased on homology to snake venom and secretions from frog skin, andhave been shown to have diverse functions. Mutations in this geneare associated with Kallmann syndrome 4. Multiple transcriptvariants encoding different isoforms have been found for this gene.
References
Catalano, R.D., et al. Mol. Hum. Reprod. 16(5):311-319(2010)Sarfati, J., et al. J. Clin. Endocrinol. Metab. 95(2):659-669(2010)Zhong, C., et al. Clin. Cancer Res. 15(8):2675-2684(2009)Canto, P., et al. J. Androl. 30(1):41-45(2009)Abreu, A.P., et al. J. Clin. Endocrinol. Metab. 93(10):4113-4118(2008)
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