KPTN Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y664 |
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Clone Names | 100603063 |
Gene ID | 11133 |
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Other Names | Kaptin, Actin-associated protein 2E4, KPTN |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KPTN (HGNC:6404) |
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Function | As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. |
Cellular Location | Lysosome membrane. Cell projection, lamellipodium. Cell projection, stereocilium {ECO:0000250|UniProtKB:A0A1D5PJB7}. Note=Localization to lysosomes is amino acid-independent (PubMed:28199306). Colocalizes with F-actin (PubMed:24239382). |
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Provided below are standard protocols that you may find useful for product applications.
Background
KPTN may be involved in actin dynamics. May play a role in producing the sensory apparatus in hair cells. May play a role in actin rearrangements that accompany platelet activation and stereocilia formation.
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Bearer, E.L., et al. Ann. Hum. Genet. 64 (PT 3), 189-196 (2000) :Bearer, E.L., et al. Eur. J. Cell Biol. 78(2):117-126(1999)Bearer, E.L. J. Neurosci. 12(3):750-761(1992)
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