GPLD1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P80108 |
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Clone Names | 100617080 |
Gene ID | 2822 |
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Other Names | Phosphatidylinositol-glycan-specific phospholipase D, PI-G PLD, Glycoprotein phospholipase D, Glycosyl-phosphatidylinositol-specific phospholipase D, GPI-PLD, GPI-specific phospholipase D, GPLD1, PIGPLD1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GPLD1 |
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Synonyms | PIGPLD1 |
Function | This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. |
Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Many proteins are tethered to the extracellular face ofeukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI)anchor. The GPI-anchor is a glycolipid found on many blood cells.The protein encoded by this gene is a GPI degrading enzyme.Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzesthe inositol phosphate linkage in proteins anchored byphosphatidylinositol glycans, thereby releasing the attachedprotein from the plasma membrane.
References
Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)Tang, J.H., et al. Clin. Biochem. 42 (4-5), 400-407 (2009) :Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008)Wright, M.H., et al. Biochem. Biophys. Res. Commun. 369(2):478-484(2008)Shi, M., et al. Cancer Lett. 258(2):268-275(2007)
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