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HAND2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P61296 |
|---|---|
| Clone Names | 100507180 |
| Gene ID | 9464 |
|---|---|
| Other Names | Heart- and neural crest derivatives-expressed protein 2, Class A basic helix-loop-helix protein 26, bHLHa26, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dHAND, HAND2, BHLHA26, DHAND |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HAND2 |
|---|---|
| Synonyms | BHLHA26, DHAND |
| Function | Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior- posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG- 3' (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. |
| Tissue Location | Heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the basichelix-loop-helix family of transcription factors. This gene productis one of two closely related family members, the HAND proteins,which are asymmetrically expressed in the developing ventricularchambers and play an essential role in cardiac morphogenesis.Working in a complementary fashion, they function in the formationof the right ventricle and aortic arch arteries, implicating themas mediators of congenital heart disease. In addition, thistranscription factor plays an important role in limb and branchialarch development.
References
Shen, L., et al. Chin. Med. J. 123(13):1623-1627(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Voth, H., et al. BMC Mol. Biol. 10, 28 (2009) :Morikawa, Y., et al. Circ. Res. 103(12):1422-1429(2008)Han, Z., et al. Development 133(6):1175-1182(2006)
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