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EIF2B3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NR50 |
|---|---|
| Clone Names | 100517310 |
| Gene ID | 8891 |
|---|---|
| Other Names | Translation initiation factor eIF-2B subunit gamma, eIF-2B GDP-GTP exchange factor subunit gamma, EIF2B3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EIF2B3 |
|---|---|
| Function | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56288} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is one of the subunits ofinitiation factor eIF2B, which catalyzes the exchange of eukaryoticinitiation factor 2-bound GDP for GTP. It has also been found tofunction as a cofactor of hepatitis C virus internal ribosome entrysite-mediated translation. Mutations in this gene have beenassociated with leukodystrophy with vanishing white matter.Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Pronk, J., et al. Mult. Scler. 14(8):1123-1126(2008)Maletkovic, J., et al. J. Child Neurol. 23(2):205-215(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Mikami, S., et al. Protein Expr. Purif. 46(2):348-357(2006)
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