Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
TJP2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UDY2 |
|---|---|
| Clone Names | 100617273 |
| Gene ID | 9414 |
|---|---|
| Other Names | Tight junction protein ZO-2, Tight junction protein 2, Zona occludens protein 2, Zonula occludens protein 2, TJP2, X104, ZO2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TJP2 (HGNC:11828) |
|---|---|
| Function | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). |
| Cellular Location | Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Z0U1}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z0U1}. Nucleus. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. Localizes to tight junctions during initial stages of their formation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q95168} |
| Tissue Location | This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a zonula occluden that is a member ofthe membrane-associated guanylate kinase homolog family. Theencoded protein functions as a component of the tight junctionbarrier in epithelial and endothelial cells and is necessary forproper assembly of tight junctions. Mutation in this gene have beenidentified in patients with hypercholanemia. Alternate splicingresults in multiple transcript variants.
References
Lechuga, S., et al. Exp. Cell Res. 316(19):3124-3139(2010)Remue, E., et al. FEBS Lett. 584(19):4175-4180(2010)Walsh, T., et al. Am. J. Hum. Genet. 87(1):101-109(2010)Meerschaert, K., et al. Cell. Mol. Life Sci. 66(24):3951-3966(2009)Fanning, A.S., et al. Ann. N. Y. Acad. Sci. 1165, 113-120 (2009) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
