FBXO31 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q5XUX0 |
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Clone Names | 110617119 |
Gene ID | 79791 |
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Other Names | F-box only protein 31, FBXO31, FBX14, FBX31 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | FBXO31 |
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Synonyms | FBX14, FBX31 |
Function | Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. |
Tissue Location | Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the F-box protein family, such as FBXO31, arecharacterized by an approximately 40-amino acid F-box motif. SCFcomplexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM603134), and F-box proteins, act as protein-ubiquitin ligases.F-box proteins interact with SKP1 through the F box, and theyinteract with ubiquitination targets through other proteininteraction domains (Jin et al., 2004 [PubMed 15520277]).[suppliedby OMIM].
References
Rivadeneira, F., et al. Nat. Genet. 41(11):1199-1206(2009)Santra, M.K., et al. Nature 459(7247):722-725(2009)Kumar, R., et al. Cancer Res. 65(24):11304-11313(2005)Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)Powell, J.A., et al. Genomics 80(3):303-310(2002)
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