P4HA1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P13674 |
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Clone Names | 100712056 |
Gene ID | 5033 |
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Other Names | Prolyl 4-hydroxylase subunit alpha-1, 4-PH alpha-1, Procollagen-proline, 2-oxoglutarate-4-dioxygenase subunit alpha-1, P4HA1, P4HA |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | P4HA1 |
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Synonyms | P4HA |
Function | Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. |
Cellular Location | Endoplasmic reticulum lumen. |
Tissue Location | Expressed in the heart, liver, skeletal muscle, kidney, placenta, lung and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a component of prolyl 4-hydroxylase, akey enzyme in collagen synthesis composed of two identical alphasubunits and two beta subunits. The encoded protein is one ofseveral different types of alpha subunits and provides the majorpart of the catalytic site of the active enzyme. In collagen andrelated proteins, prolyl 4-hydroxylase catalyzes the formation of4-hydroxyproline that is essential to the proper three-dimensionalfolding of newly synthesized procollagen chains. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Gorres, K.L., et al. PLoS ONE 4 (11), E7635 (2009) :Koivunen, P., et al. J. Biol. Chem. 281(39):28712-28720(2006)Fahling, M., et al. J. Biol. Chem. 281(36):26089-26101(2006)Grimmer, C., et al. Am. J. Pathol. 169(2):491-502(2006)
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