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TTK Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P33981 |
|---|---|
| Clone Names | 100507171 |
| Gene ID | 7272 |
|---|---|
| Other Names | Dual specificity protein kinase TTK, Phosphotyrosine picked threonine-protein kinase, PYT, TTK, MPS1, MPS1L1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TTK |
|---|---|
| Synonyms | MPS1, MPS1L1 |
| Function | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). |
| Tissue Location | Present in rapidly proliferating cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a dual specificity protein kinase withthe ability to phosphorylate tyrosine, serine and threonine.Associated with cell proliferation, this protein is essential forchromosome alignment at the centromere during mitosis and isrequired for centrosome duplication. It has been found to be acritical mitotic checkpoint protein for accurate segregation ofchromosomes during mitosis. Tumorigenesis may occur when thisprotein fails to degrade and produces excess centrosomes resultingin aberrant mitotic spindles. Alternative splicing results inmultiple transcript variants.
References
Cui, Y., et al. J. Biol. Chem. 285(43):32988-32998(2010)Maciejowski, J., et al. J. Cell Biol. 190(1):89-100(2010)Santaguida, S., et al. J. Cell Biol. 190(1):73-87(2010)Hewitt, L., et al. J. Cell Biol. 190(1):25-34(2010)Lan, W., et al. J. Cell Biol. 190(1):21-24(2010)
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