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NMNAT2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BZQ4 |
|---|---|
| Clone Names | 110717126 |
| Gene ID | 23057 |
|---|---|
| Other Names | Nicotinamide mononucleotide adenylyltransferase 2, NMN adenylyltransferase 2, Nicotinate-nucleotide adenylyltransferase 2, NaMN adenylyltransferase 2, NMNAT2, C1orf15, KIAA0479 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NMNAT2 (HGNC:16789) |
|---|---|
| Function | Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:16118205, PubMed:17402747). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed:16118205, PubMed:17402747). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:16118205, PubMed:17402747). Also acts as an activator of ADP- ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16 (PubMed:34314702). |
| Cellular Location | Golgi apparatus membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8BNJ3}; Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasm. Cell projection, axon {ECO:0000250|UniProtKB:Q8BNJ3}. Note=Delivered to axons with Golgi- derived cytoplasmic vesicles. {ECO:0000250|UniProtKB:Q8BNJ3} |
| Tissue Location | Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene product belongs to the nicotinamidemononucleotide adenylyltransferase (NMNAT) enzyme family, membersof which catalyze an essential step in NAD (NADP) biosyntheticpathway. Unlike the other human family member, which is localizedto the nucleus, and is ubiquitously expressed; this enzyme iscytoplasmic, and is predominantly expressed in the brain. Twotranscript variants encoding different isoforms have been found forthis gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lau, C., et al. J. Biol. Chem. 285(24):18868-18876(2010)Sorci, L., et al. Biochemistry 46(16):4912-4922(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Berger, F., et al. J. Biol. Chem. 280(43):36334-36341(2005)
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