PSG9 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q00887 |
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Clone Names | 100712126 |
Gene ID | 5678 |
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Other Names | Pregnancy-specific beta-1-glycoprotein 9, PS-beta-G-9, PSBG-9, Pregnancy-specific glycoprotein 9, PS34, Pregnancy-specific beta-1 glycoprotein B, PS-beta-B, Pregnancy-specific beta-1-glycoprotein 11, PS-beta-G-11, PSBG-11, Pregnancy-specific glycoprotein 11, Pregnancy-specific glycoprotein 7, PSG7, PSG9, PSG11 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PSG9 |
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Synonyms | PSG11 |
Function | Binds to the small latent transforming growth factor-beta complex, consisting of the N-terminal TGFB1 latency-associated peptide (LAP) and the mature form of TGFB1, thereby leading to the activation of TGFB1 (PubMed:27389696). The activation of TGFB1 leads to stimulation of naive CD4(+) T-cells to increase FoxP3 expression and to an increase in the number of FoxP3(+) regulatory T-cells (PubMed:27389696). Induces the differentiation of a suppressive CD4(+)LAP(+)FoxP3(-) T-cell subset (PubMed:27389696). Induces the secretion of TGFB1 in macrophages, but not in activated CD4(+) T-cells (PubMed:27389696). May reduce the expression of several pro- inflammatory cytokines and chemokines by CD4(+) T-cells, including IL2 and IL6 (PubMed:27389696). |
Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The human pregnancy-specific glycoproteins (PSGs) are agroup of molecules that are mainly produced by the placentalsyncytiotrophoblasts during pregnancy. PSGs comprise a subgroup ofthe carcinoembryonic antigen (CEA) family, which belongs to theimmunoglobulin superfamily. For additional general informationabout the PSG gene family, see PSG1 (MIM 176390).[supplied byOMIM].
References
Stelzl, U., et al. Cell 122(6):957-968(2005)Salahshor, S., et al. BMC Cancer 5, 66 (2005) :Colland, F., et al. Genome Res. 14(7):1324-1332(2004)Grimwood, J., et al. Nature 428(6982):529-535(2004)Olsen, A., et al. Genomics 23(3):659-668(1994)
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