Mouse Sik2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8CFH6 |
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Clone Names | 110328084 |
Gene ID | 235344 |
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Other Names | Serine/threonine-protein kinase SIK2, Salt-inducible kinase 2, SIK-2, Serine/threonine-protein kinase SNF1-like kinase 2, Sik2, Snf1lk2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Sik2 |
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Synonyms | Snf1lk2 |
Function | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:12624099, PubMed:16817901, PubMed:29211348). Phosphorylates 'Ser-794' of IRS1 in insulin- stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction (PubMed:12624099). Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:16817901). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity. In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (By similarity). Also plays a role in thymic T-cell development (PubMed:34732767). |
Cellular Location | Cytoplasm. |
Tissue Location | Present in both white and brown adipose tissues with levels increasing during adipocyte differentiation. Lower levels observed in the testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
References
Trivedi, C.M., et al. Dev. Cell 19(3):450-459(2010)Muraoka, M., et al. Am. J. Physiol. Endocrinol. Metab. 296 (6), E1430-E1439 (2009) :Du, J., et al. Obesity (Silver Spring) 16(3):531-538(2008)Katoh, Y., et al. FEBS J. 273(12):2730-2748(2006)Horike, N., et al. J. Biol. Chem. 278(20):18440-18447(2003)
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