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SERPINI2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75830 |
|---|---|
| Clone Names | 110717182 |
| Gene ID | 5276 |
|---|---|
| Other Names | Serpin I2, Myoepithelium-derived serine protease inhibitor, Pancpin, Pancreas-specific protein TSA2004, Peptidase inhibitor 14, PI-14, SERPINI2, MEPI, PI14 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SERPINI2 |
|---|---|
| Synonyms | MEPI, PI14 |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in pancreas and adipose tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the serineprotease inhibitor (serpin) superfamily made up of proteins whichplay central roles in the regulation of a wide variety ofphysiological processes, including coagulation, fibrinolysis,development, malignancy and inflammation. The gene product may havea role in a growth-control, possibly growth-suppressing pathwayand, when impaired, may be involved in pancreatic carcinogenesis.The protein is a member of the plasminogen activator inhibitor-1family, a subset of the serpin superfamily whose members act astissue-specific tPA inhibitors. Two alternatively splicedtranscript variants encoding distinct protein isoforms have beenfound for this gene.
References
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Lim, J., et al. Cell 125(4):801-814(2006)Chang, W.S., et al. Genes Chromosomes Cancer 29(3):240-255(2000)Xiao, G., et al. Proc. Natl. Acad. Sci. U.S.A. 96(7):3700-3705(1999)Ozaki, K., et al. Genes Chromosomes Cancer 22(3):179-185(1998)
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