ITGA2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P17301 |
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Clone Names | 100427123 |
Gene ID | 3673 |
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Other Names | Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b, ITGA2, CD49B |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ITGA2 |
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Synonyms | CD49B |
Function | Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. |
Cellular Location | Membrane; Single-pass type I membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene product belongs to the integrin alpha chainfamily. Integrins are heterodimeric integral membrane glycoproteinscomposed of a distinct alpha chain and a common beta chain. Theyare found on a wide variety of cell types including, T cells,fibroblasts and platelets. Integrins are involved in cell adhesionand also participate in cell-surface mediated signalling. [providedby RefSeq].
References
Nie, Y.M., et al. Transfus Med 20(6):376-382(2010)Motovska, Z., et al. Atherosclerosis 212(2):548-552(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Hozumi, K., et al. FEBS Lett. 584(15):3381-3385(2010)Wang, Y., et al. Diabet. Med. 27(4):376-383(2010)
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