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ECSCR Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q19T08 |
|---|---|
| Clone Names | 91216183 |
| Gene ID | 641700 |
|---|---|
| Other Names | Endothelial cell-specific chemotaxis regulator, Apoptosis regulator through modulating IAP expression, ARIA, Endothelial cell-specific molecule 2, ECSCR, ECSM2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ECSCR |
|---|---|
| Synonyms | ECSM2 |
| Function | Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cytoplasm |
| Tissue Location | Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is primarily found inendothelial cells and blood vessels, where it may be involved incell shape changes and EGF-induced cell migration. This gene couldplay a role in angiogenesis-related diseases.
References
Ikeda, K., et al. Proc. Natl. Acad. Sci. U.S.A. 106(20):8227-8232(2009)Ma, F., et al. Genes Cells 14(3):281-293(2009)Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :Armstrong, L.J., et al. Arterioscler. Thromb. Vasc. Biol. 28(9):1640-1646(2008)
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