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ZFP57 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NU63 |
|---|---|
| Clone Names | 110811266 |
| Gene ID | 346171 |
|---|---|
| Other Names | Zinc finger protein 57 homolog, Zfp-57, Zinc finger protein 698, ZFP57, C6orf40, ZNF698 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZFP57 (HGNC:18791) |
|---|---|
| Synonyms | C6orf40, ZNF698 |
| Function | Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:18622393, PubMed:30602440). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). |
| Cellular Location | Nucleus. Note=Binds various differentially methylated regions (DMR) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a zinc finger proteincontaining a KRAB domain. Studies in mouse suggest that thisprotein may function as a transcriptional repressor. Mutations inthis gene have been associated with transient neonatal diabetesmellitus type 1 (TNDM1).
References
Spengler, S., et al. Eur J Med Genet 52(6):415-416(2009)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :Tse, K.P., et al. Am. J. Hum. Genet. 85(2):194-203(2009)Li, X., et al. Dev. Cell 15(4):547-557(2008)Mackay, D.J., et al. Nat. Genet. 40(8):949-951(2008)
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