BRUNOL5 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N6W0 |
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Clone Names | 90429051 |
Gene ID | 60680 |
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Other Names | CUGBP Elav-like family member 5, CELF-5, Bruno-like protein 5, CUG-BP- and ETR-3-like factor 5, RNA-binding protein BRUNOL-5, CELF5, BRUNOL5 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CELF5 |
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Synonyms | BRUNOL5 |
Function | RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. |
Cellular Location | Nucleus. Cytoplasm. |
Tissue Location | Expressed in brain.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the CELF/BRUNOL protein family contain twoN-terminal RNA recognition motif (RRM) domains, one C-terminal RRMdomain, and a divergent segment of 160-230 aa between the secondand third RRM domains. Members of this protein family regulatepre-mRNA alternative splicing and may also be involved in mRNAediting, and translation. Alternatively spliced transcript variantshave been identified in this gene.
References
Ladd, A.N., et al. Mol. Cell. Biol. 21(4):1285-1296(2001)Good, P.J., et al. J. Biol. Chem. 275(37):28583-28592(2000)
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