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NAAA Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q02083 |
|---|---|
| Clone Names | 110819076 |
| Gene ID | 27163 |
|---|---|
| Other Names | N-acylethanolamine-hydrolyzing acid amidase, 351-, Acid ceramidase-like protein, N-acylsphingosine amidohydrolase-like, ASAH-like protein, N-acylethanolamine-hydrolyzing acid amidase subunit alpha, N-acylethanolamine-hydrolyzing acid amidase subunit beta, NAAA, ASAHL, PLT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NAAA {ECO:0000303|PubMed:30301806, ECO:0000312|HGNC:HGNC:736} |
|---|---|
| Function | Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N- myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine (PubMed:15655246, PubMed:17980170, PubMed:18793752, PubMed:30301806, PubMed:22825852). Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine (PubMed:15655246). |
| Cellular Location | Lysosome. Membrane; Peripheral membrane protein |
| Tissue Location | Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an N-acylethanolamine-hydrolyzing enzymewhich is highly similar to acid ceramidase. Multiple transcriptvariants encoding different isoforms have been found for this gene.
References
Wang, J., et al. J. Biochem. 144(5):685-690(2008)Muller, T.D., et al. Child Adolesc Psychiatry Ment Health 2 (1), 33 (2008) :Schulze, H., et al. Biol. Chem. 388(12):1333-1343(2007)Zhao, L.Y., et al. Biochim. Biophys. Acta 1771(11):1397-1405(2007)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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