HOXD8 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P13378 |
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Clone Names | 110328174 |
Gene ID | 3234 |
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Other Names | Homeobox protein Hox-D8, Homeobox protein Hox-4E, Homeobox protein Hox-54, HOXD8, HOX4E |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HOXD8 |
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Synonyms | HOX4E |
Function | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the homeobox family of genes. Thehomeobox genes encode a highly conserved family of transcriptionfactors that play an important role in morphogenesis in allmulticellular organisms. Mammals possess four similar homeobox geneclusters, HOXA, HOXB, HOXC and HOXD, located on differentchromosomes, consisting of 9 to 11 genes arranged in tandem. Thisgene is one of several homeobox HOXD genes located in a cluster onchromosome 2. Deletions that remove the entire HOXD gene cluster orthe 5' end of this cluster have been associated with severe limband genital abnormalities. In addition to effects duringembryogenesis, this particular gene may also play a role in adulturogenital tract function.
References
Ester, A.R., et al. Am. J. Med. Genet. A 149A (12), 2745-2752 (2009) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Harada, K., et al. J. Cell. Sci. 122 (PT 21), 3923-3930 (2009) :Goodman, F.R. Am. J. Med. Genet. 112(3):256-265(2002)Kosaki, K., et al. Teratology 65(2):50-62(2002)
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