RARRES3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UL19 |
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Clone Names | 100623024 |
Gene ID | 5920 |
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Other Names | Retinoic acid receptor responder protein 3, 311-, HRAS-like suppressor 4, HRSL4, RAR-responsive protein TIG3, Retinoid-inducible gene 1 protein, Tazarotene-induced gene 3 protein, RARRES3, RIG1, TIG3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PLAAT4 (HGNC:9869) |
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Synonyms | RARRES3, RIG1, TIG3 |
Function | Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O- acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which serves as precursor for N- acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). Promotes keratinocyte differentiation via activation of TGM1 (PubMed:17762858). |
Cellular Location | Membrane; Single- pass membrane protein |
Tissue Location | Widely expressed. |
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Background
Retinoids exert biologic effects such as potent growthinhibitory and cell differentiation activities and are used in thetreatment of hyperproliferative dermatological diseases. Theseeffects are mediated by specific nuclear receptor proteins that aremembers of the steroid and thyroid hormone receptor superfamily oftranscriptional regulators. RARRES1, RARRES2, and RARRES3 are geneswhose expression is upregulated by the synthetic retinoidtazarotene. RARRES3 is thought act as a tumor suppressor or growthregulator.
References
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Uyama, T., et al. Biochim. Biophys. Acta 1791(12):1114-1124(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Higuchi, E., et al. Oncogene 22(30):4627-4635(2003)
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