RRAGB Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q5VZM2 |
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Clone Names | 110717167 |
Gene ID | 10325 |
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Other Names | Ras-related GTP-binding protein B, Rag B, RagB, RRAGB (HGNC:19901) |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RRAGB (HGNC:19901) |
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Function | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagB/RRAGB is in its active form when GTP-bound RagB/RRAGB forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagB/RRAGB heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:18497260, PubMed:20381137, PubMed:23723238). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008). |
Cellular Location | Cytoplasm. Lysosome membrane. Note=Recruited to the lysosome surface by the Ragulator complex. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ras-homologous GTPases constitute a large family of signaltransducers that alternate between an activated, GTP-binding stateand an inactivated, GDP-binding state. These proteins representcellular switches that are operated by GTP-exchange factors andfactors that stimulate their intrinsic GTPase activity. All GTPasesof the Ras superfamily have in common the presence of six conservedmotifs involved in GTP/GDP binding, three of which arephosphate-/magnesium-binding sites (PM1-PM3) and three of which areguanine nucleotide-binding sites (G1-G3). Transcript variantsencoding distinct isoforms have been identified. [provided byRefSeq].
References
Ross, M.T., et al. Nature 434(7031):325-337(2005)Tomarev, S.I., et al. Invest. Ophthalmol. Vis. Sci. 44(6):2588-2596(2003)Sekiguchi, T., et al. J. Biol. Chem. 276(10):7246-7257(2001)Hirose, E., et al. J. Cell. Sci. 111 (PT 1), 11-21 (1998) :Schurmann, A., et al. J. Biol. Chem. 270(48):28982-28988(1995)
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