SLCO1C1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NYB5 |
---|---|
Clone Names | 100324034 |
Gene ID | 53919 |
---|---|
Other Names | Solute carrier organic anion transporter family member 1C1, Organic anion transporter F, OATP-F, Organic anion transporter polypeptide-related protein 5, OAT-RP-5, OATPRP5, Organic anion-transporting polypeptide 14, OATP-14, Solute carrier family 21 member 14, Thyroxine transporter, SLCO1C1, OATP14, OATP1C1, OATPF, SLC21A14 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLCO1C1 |
---|---|
Synonyms | OATP14, OATP1C1, OATPF, SLC21A14 |
Function | Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L- thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed:12351693, PubMed:18566113, PubMed:19129463). Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed:18566113). Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed:18566113). Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D- glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed:12351693, PubMed:19129463). Transports T4 and E1S in a pH-insensitive manner (PubMed:19129463). Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed:30296914). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus |
Tissue Location | Highly expressed in brain and in Leydig cells in testis (PubMed:12351693, PubMed:35307651). Localized in nests of Leydig cells (at protein level) (PubMed:12351693). Expressed in choroid plexus (at protein level) (PubMed:18687783). Not strongly enriched in cerebral microvessels (PubMed:18687783). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the organic aniontransporter family. The encoded protein is a transmembrane receptorthat mediates the sodium-independent uptake of thyroid hormones inbrain tissues. This protein has particularly high affinity for thethyroid hormones thyroxine, tri-iodothyronine and reversetri-iodothyronine. Polymorphisms in the gene encoding this proteinmay be associated with fatigue and depression in patients sufferingfrom hyperthyroidism. Alternative splicing results in multipletranscript variants.
References
Franke, R.M., et al. Pharmacogenomics 10(3):339-344(2009)Heuer, H., et al. Endocrinology 150(3):1078-1083(2009)Leuthold, S., et al. Am. J. Physiol., Cell Physiol. 296 (3), C570-C582 (2009) :Westholm, D.E., et al. Endocrinology 150(2):1025-1032(2009)Roberts, L.M., et al. Endocrinology 149(12):6251-6261(2008)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.