CALHM3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86XJ0 |
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Clone Names | 100422094 |
Gene ID | 119395 |
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Other Names | Calcium homeostasis modulator protein 3, Protein FAM26A, CALHM3, FAM26A |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CALHM3 (HGNC:23458) |
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Synonyms | FAM26A |
Function | Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances. |
Cellular Location | Basolateral cell membrane {ECO:0000250|UniProtKB:J3QMI4}; Multi-pass membrane protein |
Tissue Location | Specifically expressed in circumvallate taste bud cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of CALHM3 remains unknown. There are two different isoforms generated by alternative splicing.
References
Shibata, N., et al. J. Alzheimers Dis. 20(2):417-421(2010)Dreses-Werringloer, U., et al. Cell 133(7):1149-1161(2008)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Deloukas, P., et al. Nature 429(6990):375-381(2004)
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