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ARPC2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O15144
Clone Names 100517041
Additional Information
Gene ID 10109
Other Names Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34 kDa subunit, p34-ARC, ARPC2, ARC34
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARPC2
Synonyms ARC34
Function Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Cellular Location Cytoplasm, cytoskeleton. Cell projection. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q9CVB6}. Nucleus
Research Areas
Citations (0)

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Background

This gene encodes one of seven subunits of the humanArp2/3 protein complex. The Arp2/3 protein complex has beenimplicated in the control of actin polymerization in cells and hasbeen conserved through evolution. The exact role of the proteinencoded by this gene, the p34 subunit, has yet to be determined.Two alternatively spliced variants have been characterized to date.Additional alternatively spliced variants have been described buttheir full length nature has not been determined. [provided byRefSeq].

References

Monfregola, J., et al. J. Biol. Chem. 285(22):16951-16957(2010)Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)Franke, A., et al. Nat. Genet. 40(11):1319-1323(2008)Xiao, F., et al. Brain Res. 1233, 168-175 (2008) :Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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$ 277.78
Cat# BP18993b
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