|Other Names||Ras-related protein Ral-A, RALA, RAL|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269).|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody, Midbody ring. Note=Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles (PubMed:19306925). May colocalize with CNTRL/centriolin at the midbody ring (PubMed:16213214). However, localization at the midbody at late cytokinesis was not confirmed (PubMed:18756269).|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the small GTPasesuperfamily, Ras family of proteins. GTP-binding proteins mediatethe transmembrane signaling initiated by the occupancy of certaincell surface receptors. This gene encodes a low molecular massras-like GTP-binding protein that shares about 50% similarity withother ras proteins.
Nichols, C.D., et al. Curr. Biol. 20(14):1316-1320(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Godin, C.M., et al. Mol. Pharmacol. 77(3):388-395(2010)Lim, K.H., et al. Mol. Cell. Biol. 30(2):508-523(2010)Wang, K., et al. Int J Immunopathol Pharmacol 22(3):735-743(2009)
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