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Mouse Cdk6 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q64261
Clone Names 110316095
Additional Information
Gene ID 12571
Other Names Cyclin-dependent kinase 6, CR2 protein kinase, CRK2, Cell division protein kinase 6, Serine/threonine-protein kinase PLSTIRE, Cdk6, Cdkn6, Crk2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cdk6
Synonyms Cdkn6, Crk2
Function Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans (By similarity). May play a role in the centrosome organization during the cell cycle phases.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q00534}. Nucleus {ECO:0000250|UniProtKB:Q00534}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q00534}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q00534} Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (By similarity). Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus. {ECO:0000250|UniProtKB:Q00534, ECO:0000269|PubMed:23918663}
Tissue Location Expressed in subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) and the subventricular zone (SVZ) of the lateral ventricles whose neural precursor cells (NPC) give rise to dentate granule neurons and olfactory bulb (OB) interneurons, respectively. Expressed in the neuroepithelium of the cerebral cortex of the developing brain.
Research Areas
Citations (0)

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Cdk6 probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins (By similarity).


Puyol, M., et al. Cancer Cell 18(1):63-73(2010)Wiedemeyer, W.R., et al. Proc. Natl. Acad. Sci. U.S.A. 107(25):11501-11506(2010)Rivadeneira, D.B., et al. Gastroenterology 138(5):1920-1930(2010)Michaud, K., et al. Cancer Res. 70(8):3228-3238(2010)Choe, K.S., et al. J. Biol. Chem. 285(5):3044-3052(2010)

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$ 277.78
Cat# BP19011b
Availability: 2 weeks
Bulk Size

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