|Other Names||Signal peptide, CUB and EGF-like domain-containing protein 3, SCUBE3 (HGNC:13655)|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.|
|Cellular Location||Secreted. Cell surface|
|Tissue Location||Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up- regulated in lung cancer cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
SCUBE3 contains one CUB domain and 9 EGF-like domains. It is highly expressed in primary osteoblasts and the long bones (humerus and femur) and expression is low or absent in non-bone tissues. It may play an important role in bone cell biology.
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Wu, B.T., et al. J. Biol. Chem. 279(36):37485-37490(2004)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Yang, R.B., et al. J. Biol. Chem. 277(48):46364-46373(2002)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.