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Sin3A Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96ST3
Clone Names 5082259
Additional Information
Gene ID 25942
Other Names Paired amphipathic helix protein Sin3a, Histone deacetylase complex subunit Sin3a, Transcriptional corepressor Sin3a, SIN3A (HGNC:19353)
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1907c was selected from the Center region of human Sin3A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIN3A (HGNC:19353)
Function Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810, ECO:0000269|PubMed:16820529}. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L
Tissue Location Expressed in the developing brain, with highest levels of expression detected in the ventricular zone of various cortical regions.
Research Areas
Citations (0)

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Background

Sin3A is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. Sin3A also interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities.

References

Tong, Y., et al., Proc. Natl. Acad. Sci. U.S.A. 102(6):2034-2039 (2005).Tanikawa, J., et al., J. Biol. Chem. 279(53):55393-55400 (2004).Kemper, J.K., et al., Mol. Cell. Biol. 24(17):7707-7719 (2004).Zou, J., et al., J. Biol. Chem. 279(15):14922-14928 (2004).Wysocka, J., et al., Genes Dev. 17(7):896-911 (2003).

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$ 277.78
Cat# BP1907c
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Availability: 2 weeks
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