TBCB Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q99426 |
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Clone Names | 110901183 |
Gene ID | 1155 |
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Other Names | Tubulin-folding cofactor B, Cytoskeleton-associated protein 1, Cytoskeleton-associated protein CKAPI, Tubulin-specific chaperone B, TBCB, CG22, CKAP1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TBCB |
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Synonyms | CG22, CKAP1 |
Function | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). |
Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone. |
Tissue Location | Found in most tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TBCB binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Cleveland, D.W., et al. Hum. Mol. Genet. 18(8):1384-1394(2009)Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Fanarraga, M.L., et al. Exp. Cell Res. 315(3):535-541(2009)
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