|Other Names||ATPase WRNIP1, Werner helicase-interacting protein 1, WRNIP1 (HGNC:20876)|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG- I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.|
|Cellular Location||Nucleus. Cytoplasm. Note=Colocalizes with WRN in granular structures in the nucleus.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Werner's syndrome is a rare autosomal recessive disordercharacterized by premature aging. The protein encoded by this geneinteracts with the N-terminal portion of Werner protein containingthe exonuclease domain. This protein shows homology to replicationfactor C family proteins, and is conserved from E. coli to human.Studies in yeast suggest that this gene may influence the agingprocess. Two transcript variants encoding different isoforms havebeen isolated for this gene.
Kaur, S., et al. Cell Cycle 9(15):3106-3111(2010)Yoshimura, A., et al. Genes Genet. Syst. 84(2):171-178(2009)Crosetto, N., et al. J. Biol. Chem. 283(50):35173-35185(2008)Mano, Y., et al. Cancer Sci. 98(12):1902-1913(2007)Bish, R.A., et al. J. Biol. Chem. 282(32):23184-23193(2007)
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