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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   GAS41 (YEATS4/NuBI-1) Antibody (N-term A31) Blocking peptide   

GAS41 (YEATS4/NuBI-1) Antibody (N-term A31) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O95619
Clone Names 5081955
Additional Information
Gene ID 8089
Other Names YEATS domain-containing protein 4, Glioma-amplified sequence 41, Gas41, NuMA-binding protein 1, NuBI-1, NuBI1, YEATS4, GAS41
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1910a was selected from the N-term region of human NuBI-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name YEATS4 (HGNC:24859)
Function Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12963728, PubMed:14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed:29437725, PubMed:30071723, PubMed:29900004). Also able to recognize and bind crotonylated histone H3 (PubMed:30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (PubMed:29463709). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (PubMed:29437725). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00376, ECO:0000269|PubMed:10913114}
Tissue Location Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
Research Areas
Citations (0)

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Background

NuBI-1 is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. The gene for this protein has been shown to be amplified in tumors.

References

Cai, Y., et al., J. Biol. Chem. 278(44):42733-42736 (2003).Lauffart, B., et al., Genomics 81(2):192-201 (2003).Zimmermann, K., et al., J. Biol. Chem. 277(21):18626-18631 (2002).Debernardi, S., et al., Blood 99(1):275-281 (2002).Munnia, A., et al., Oncogene 20(35):4853-4863 (2001).

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$ 277.78
Cat# BP1910a
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