|Other Names||Replication factor C subunit 1, Activator 1 140 kDa subunit, A1 140 kDa subunit, Activator 1 large subunit, Activator 1 subunit 1, DNA-binding protein PO-GA, Replication factor C 140 kDa subunit, RF-C 140 kDa subunit, RFC140, Replication factor C large subunit, RFC1, RFC140|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.|
|Tissue Location||Wide tissue distribution. Undetectable in placental tissue|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is the large subunit ofreplication factor C, which is a five subunit DNA polymeraseaccessory protein. Replication factor C is a DNA-dependent ATPasethat is required for eukaryotic DNA replication and repair. Theprotein acts as an activator of DNA polymerases, binds to the 3'end of primers, and promotes coordinated synthesis of both strands.It also may have a role in telomere stability. [provided byRefSeq].
Overmeer, R.M., et al. Mol. Cell. Biol. 30(20):4828-4839(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Arora, M., et al. Leukemia 24(8):1470-1475(2010)Galbiatti, A.L., et al. Mol. Biol. Rep. (2010) In press :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.