PES1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O00541 |
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Clone Names | 100517064 |
Gene ID | 23481 |
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Other Names | Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028}, PES1 {ECO:0000255|HAMAP-Rule:MF_03028} |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PES1 {ECO:0000255|HAMAP-Rule:MF_03028} |
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Function | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255|HAMAP- Rule:MF_03028} |
Tissue Location | Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is abnormally elevated inmalignant tumors of astrocytic origin. It is a strongly conservedgene containing a BRCT domain that is essential for the activity ofthis gene product. The gene plays a crucial role in cellproliferation and may be necessary for oncogenic transformation andtumor progression.
References
Zhang, J., et al. Acta Biochim. Biophys. Sin. (Shanghai) 41(12):991-997(2009)Li, J., et al. Cancer Sci. 100(12):2255-2260(2009)Rikova, K., et al. Cell 131(6):1190-1203(2007)Rohrmoser, M., et al. Mol. Cell. Biol. 27(10):3682-3694(2007)Grimm, T., et al. Nucleic Acids Res. 34(10):3030-3043(2006)
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