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ACCN3 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UHC3
Clone Names 100517115
Additional Information
Gene ID 9311
Other Names Acid-sensing ion channel 3, ASIC3, hASIC3, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Testis sodium channel 1, hTNaC1, ASIC3, ACCN3, SLNAC1, TNAC1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASIC3
Synonyms ACCN3, SLNAC1, TNAC1
Function Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity).
Tissue Location Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.
Research Areas
Citations (0)

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This gene encodes a member of the degenerin/epithelialsodium channel (DEG/ENaC) superfamily. The members of this familyare amiloride-sensitive sodium channels that contain intracellularN and C termini, two hydrophobic transmembrane regions, and a largeextracellular loop, which has many cysteine residues with conservedspacing. The member encoded by this gene is an acid sensor and mayplay an important role in the detection of lasting pH changes. Inaddition, a heteromeric association between this member and ACCN1has been observed as proton-gated channels sensitive to gadolinium.Alternative splicing of this gene generates three transcriptvariants encoding distinct isoforms.


Borzan, J., et al. Anesthesiology 113(3):647-654(2010)Wu, S., et al. Clin. Chim. Acta 411 (15-16), 1132-1136 (2010) :Ko, Y.L., et al. J. Hypertens. 26(11):2154-2160(2008)Su, X., et al. J. Biol. Chem. 281(48):36960-36968(2006)Jones, N.G., et al. J. Neurosci. 24(48):10974-10979(2004)

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$ 277.78
Cat# BP19124a
Availability: 2 weeks
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