KDELR1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P24390 |
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Clone Names | 110826222 |
Gene ID | 10945 |
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Other Names | ER lumen protein-retaining receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, KDEL receptor 1, Putative MAPK-activating protein PM23, KDELR1, ERD21 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KDELR1 |
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Synonyms | ERD2.1 |
Function | Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. |
Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:P33946}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946} Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L |
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Provided below are standard protocols that you may find useful for product applications.
Background
Retention of resident soluble proteins in the lumen of theendoplasmic reticulum (ER) is achieved in both yeast and animalcells by their continual retrieval from the cis-Golgi, or apre-Golgi compartment. Sorting of these proteins is dependent on aC-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) inanimal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. Thisprocess is mediated by a receptor that recognizes, and binds thetetrapeptide-containing protein, and returns it to the ER. Inyeast, the sorting receptor encoded by a single gene, ERD2, whichis a seven-transmembrane protein. Unlike yeast, several humanhomologs of the ERD2 gene, constituting the KDEL receptor genefamily, have been described. The protein encoded by this gene wasthe first member of the family to be identified, and it encodes aprotein structurally and functionally similar to the yeast ERD2gene product.
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Breuza, L., et al. J. Biol. Chem. 279(45):47242-47253(2004)Bard, F., et al. J. Biol. Chem. 278(47):46601-46606(2003)Yamamoto, K., et al. J. Biol. Chem. 278(36):34525-34532(2003)Matsuda, A., et al. Oncogene 22(21):3307-3318(2003)
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