Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
SLC25A20 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43772 |
|---|---|
| Clone Names | 100318241 |
| Gene ID | 788 |
|---|---|
| Other Names | Mitochondrial carnitine/acylcarnitine carrier protein, Carnitine/acylcarnitine translocase, CAC, Solute carrier family 25 member 20, SLC25A20, CAC, CACT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC25A20 (HGNC:1421) |
|---|---|
| Synonyms | CAC, CACT |
| Function | Mediates the electroneutral exchange of acylcarnitines (O- acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)- carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (PubMed:12892634, PubMed:18307102) (Probable). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) (PubMed:18307102). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene product is one of several closely relatedmitochondrial-membrane carrier proteins that shuttle substratesbetween cytosol and the intramitochondrial matrix space. Thisprotein mediates the transport of acylcarnitines into mitochondrialmatrix for their oxidation by the mitochondrial fattyacid-oxidation pathway. Mutations in this gene are associated withcarnitine-acylcarnitine translocase deficiency, which can cause avariety of pathological conditions such as hypoglycemia, cardiacarrest, hepatomegaly, hepatic dysfunction and muscle weakness, andis usually lethal in new born and infants.
References
Tachibana, K., et al. Biochem. Biophys. Res. Commun. 389(3):501-505(2009)De Lucas, J.R., et al. Mol. Membr. Biol. 25(2):152-163(2008)Pierre, G., et al. J. Inherit. Metab. Dis. 30 (5), 815 (2007) :Peluso, G., et al. J. Cell. Physiol. 203(2):439-446(2005)Kahn, B.B., et al. Cell Metab. 1(1):15-25(2005)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
