|Other Names||Mitochondrial carnitine/acylcarnitine carrier protein, Carnitine/acylcarnitine translocase, CAC, Solute carrier family 25 member 20, SLC25A20, CAC, CACT|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene product is one of several closely relatedmitochondrial-membrane carrier proteins that shuttle substratesbetween cytosol and the intramitochondrial matrix space. Thisprotein mediates the transport of acylcarnitines into mitochondrialmatrix for their oxidation by the mitochondrial fattyacid-oxidation pathway. Mutations in this gene are associated withcarnitine-acylcarnitine translocase deficiency, which can cause avariety of pathological conditions such as hypoglycemia, cardiacarrest, hepatomegaly, hepatic dysfunction and muscle weakness, andis usually lethal in new born and infants.
Tachibana, K., et al. Biochem. Biophys. Res. Commun. 389(3):501-505(2009)De Lucas, J.R., et al. Mol. Membr. Biol. 25(2):152-163(2008)Pierre, G., et al. J. Inherit. Metab. Dis. 30 (5), 815 (2007) :Peluso, G., et al. J. Cell. Physiol. 203(2):439-446(2005)Kahn, B.B., et al. Cell Metab. 1(1):15-25(2005)
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