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NUP50 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UKX7
Other Accession Q8N6V5
Clone Names 5082260
Additional Information
Gene ID 10762
Other Names Nuclear pore complex protein Nup50, 50 kDa nucleoporin, Nuclear pore-associated protein 60 kDa-like, Nucleoporin Nup50, NUP50, NPAP60L
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1913b was selected from the C-term region of human NUP50. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NUP50
Synonyms NPAP60L
Function Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity).
Cellular Location Nucleus, nuclear pore complex. Nucleus membrane {ECO:0000250|UniProtKB:O08587}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08587}; Nucleoplasmic side {ECO:0000250|UniProtKB:O08587}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis (PubMed:12802065) Associates with the newly formed nuclear membrane during telophase (PubMed:12802065). In the testis, the localization changes during germ cell differentiation from the nuclear surface in spermatocytes to the whole nucleus (interior) in spermatids and back to the nuclear surface in spermatozoa (By similarity). {ECO:0000250|UniProtKB:O08587, ECO:0000269|PubMed:12802065}
Tissue Location Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver
Research Areas
Citations (0)

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The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. NUP50 is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. NUP50 may serve as a binding site on the nuclear side of the pore complex for export receptor-cargo complexes. It interacts with multiple transport receptor proteins including p27Kip1. This interaction is required for correct intracellular transport and degradation of p27Kip1.


Lindsay, M.E., et al., Cell 110(3):349-360 (2002).Swaminathan, S., et al., Dev. Cell 3(3):304-306 (2002).Smitherman, M., et al., Mol. Cell. Biol. 20(15):5631-5642 (2000).Guan, T., et al., Mol. Cell. Biol. 20(15):5619-5630 (2000).Collins, J.E., et al., Genome Biol. 5 (10), R84 (2004) (): ().

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$ 277.78
Cat# BP1913b
Availability: 2 weeks
Bulk Size

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