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RHCG Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UBD6 |
|---|---|
| Clone Names | 100318274 |
| Gene ID | 51458 |
|---|---|
| Other Names | Ammonium transporter Rh type C, Rh glycoprotein kidney, Rhesus blood group family type C glycoprotein, Rh family type C glycoprotein, Rh type C glycoprotein, Tumor-related protein DRC2, RHCG, C15orf6, CDRC2, PDRC2, RHGK |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RHCG |
|---|---|
| Synonyms | C15orf6, CDRC2, PDRC2, RHGK |
| Function | Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (PubMed:11062476, PubMed:14761968, PubMed:15929723, PubMed:16477434, PubMed:16580862, PubMed:24077989). May act as a CO2 channel providing for renal acid secretion (PubMed:24077989). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral membrane and in subapical vesicles. |
| Tissue Location | Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). Expressed in kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
RHCG functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gruswitz, F., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9638-9643(2010)Mouro-Chanteloup, I., et al. PLoS ONE 5 (1), E8921 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Han, K.H., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 297 (1), L153-L163 (2009) :
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