|Other Names||Gamma-secretase subunit APH-1A, APH-1a, Aph-1alpha, Presenilin-stabilization factor, APH1A, PSF|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12763021, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Required for normal gamma-secretase assembly (PubMed:12522139, PubMed:12471034, PubMed:12763021, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi|
|Tissue Location||Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
APH1 is a multipass transmembrane protein that interactswith presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM605254) as a functional component of the gamma-secretase complex.The gamma-secretase complex is required for the intramembraneproteolysis of a number of membrane proteins, including theamyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM190198).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Mitsuishi, Y., et al. J. Biol. Chem. 285(20):14920-14931(2010)Chen, A.C., et al. J. Biol. Chem. 285(15):11378-11391(2010)Pardossi-Piquard, R., et al. J. Biol. Chem. 284(24):16298-16307(2009)Wang, Y., et al. Neurosci. Lett. 455(2):101-104(2009)
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