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APH1A Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96BI3 |
|---|---|
| Clone Names | 100430060 |
| Gene ID | 51107 |
|---|---|
| Other Names | Gamma-secretase subunit APH-1A, APH-1a, Aph-1alpha, Presenilin-stabilization factor, APH1A, PSF |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | APH1A |
|---|---|
| Synonyms | PSF |
| Function | Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12763021, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Required for normal gamma-secretase assembly (PubMed:12522139, PubMed:12471034, PubMed:12763021, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi |
| Tissue Location | Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level. |
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Provided below are standard protocols that you may find useful for product applications.
Background
APH1 is a multipass transmembrane protein that interactswith presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM605254) as a functional component of the gamma-secretase complex.The gamma-secretase complex is required for the intramembraneproteolysis of a number of membrane proteins, including theamyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM190198).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Mitsuishi, Y., et al. J. Biol. Chem. 285(20):14920-14931(2010)Chen, A.C., et al. J. Biol. Chem. 285(15):11378-11391(2010)Pardossi-Piquard, R., et al. J. Biol. Chem. 284(24):16298-16307(2009)Wang, Y., et al. Neurosci. Lett. 455(2):101-104(2009)
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