|Other Names||Repulsive guidance molecule A, RGM domain family member A, RGMA, RGM|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA- ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG- PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1- AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI- anchor|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the repulsive guidancemolecule family. The encoded protein is aglycosylphosphatidylinositol-anchored glycoprotein that functionsas an axon guidance protein in the developing and adult centralnervous system. This protein may also function as a tumorsuppressor in some cancers. Alternate splicing results in multipletranscript variants.
Nohra, R., et al. Genes Immun. 11(4):279-293(2010)Severyn, C.J., et al. Biochem. J. 422(3):393-403(2009)Li, V.S., et al. Gastroenterology 137(1):176-187(2009)Endo, M., et al. J. Neurosci. 29(20):6649-6662(2009)Hata, K., et al. J. Cell Biol. 184(5):737-750(2009)
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