TEF Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q10587 |
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Clone Names | 110901191 |
Gene ID | 7008 |
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Other Names | Thyrotroph embryonic factor, TEF, KIAA1655 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TEF |
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Synonyms | KIAA1655 |
Function | Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3'. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Thyrotroph embryonic factor (TEF), a transcription factor,is a member of the PAR (proline and acidic amino acid-rich)subfamily of basic region/leucine zipper (bZIP) transcriptionfactors. It is expressed in a broad range of cells and tissues inadult animals, however, during embryonic development, TEFexpression appears to be restricted to the developing anteriorpituitary gland, coincident with the appearance ofthyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to,and transactivate the TSHB promoter. It shows homology (in thefunctional domains) with other members of the PAR-bZIP subfamily oftranscription factors, which include albumin D box-binding protein(DBP), human hepatic leukemia factor (HLF) and chicken vitellogeningene-binding protein (VBP); VBP is considered the chicken homologueof TEF. Different members of the subfamily can readily formheterodimers, and share DNA-binding, and transcriptional regulatoryproperties. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
References
Kripke, D.F., et al. Psychiatry Investig 7(1):36-42(2010)Inukai, T., et al. Blood 105(11):4437-4444(2005)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :Newman, J.R., et al. Science 300(5628):2097-2101(2003)Hirosawa, M., et al. DNA Res. 8(1):1-9(2001)
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