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TEF Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q10587
Clone Names 110901191
Additional Information
Gene ID 7008
Other Names Thyrotroph embryonic factor, TEF, KIAA1655
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TEF
Synonyms KIAA1655
Function Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3'.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Thyrotroph embryonic factor (TEF), a transcription factor,is a member of the PAR (proline and acidic amino acid-rich)subfamily of basic region/leucine zipper (bZIP) transcriptionfactors. It is expressed in a broad range of cells and tissues inadult animals, however, during embryonic development, TEFexpression appears to be restricted to the developing anteriorpituitary gland, coincident with the appearance ofthyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to,and transactivate the TSHB promoter. It shows homology (in thefunctional domains) with other members of the PAR-bZIP subfamily oftranscription factors, which include albumin D box-binding protein(DBP), human hepatic leukemia factor (HLF) and chicken vitellogeningene-binding protein (VBP); VBP is considered the chicken homologueof TEF. Different members of the subfamily can readily formheterodimers, and share DNA-binding, and transcriptional regulatoryproperties. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].

References

Kripke, D.F., et al. Psychiatry Investig 7(1):36-42(2010)Inukai, T., et al. Blood 105(11):4437-4444(2005)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :Newman, J.R., et al. Science 300(5628):2097-2101(2003)Hirosawa, M., et al. DNA Res. 8(1):1-9(2001)

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$ 277.78
Cat# BP19200b
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