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Mouse Sash1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P59808
Clone Names 110919024
Additional Information
Gene ID 70097
Other Names SAM and SH3 domain-containing protein 1, Sash1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sash1
Function Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:O94885}.
Tissue Location Expressed in the microvascular endothelium of various organs, as well as in parenchymal cells. Expressed in the endothelium but not lymphoid cells of spleen and thymus
Research Areas
Citations (0)
citation

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Background

Sash1 may have a role in a signaling pathway. Could act as a tumor suppressor.

References

Trinidad, J.C., et al. Mol. Cell Proteomics 5(5):914-922(2006)Lindvall, J.M., et al. Cell. Immunol. 235(1):46-55(2005)Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)Okazaki, N., et al. DNA Res. 10(4):167-180(2003)Carninci, P., et al. Genome Res. 13 (6B), 1273-1289 (2003) :

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$ 277.78
Cat# BP19222b
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