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Mouse Sash1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P59808
Clone Names 110919024
Additional Information
Other Names SAM and SH3 domain-containing protein 1, Sash1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sash1
Function Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:O94885}.
Tissue Location Expressed in the microvascular endothelium of various organs, as well as in parenchymal cells. Expressed in the endothelium but not lymphoid cells of spleen and thymus EMBL; AJ507736; CAD47812.1; -; mRNA CCDS; CCDS23692.1; - RefSeq; NP_780364.3; NM_175155.4 SMR; P59808; - BioGRID; 213862; 2 STRING; 10090.ENSMUSP00000015449; - iPTMnet; P59808; - PhosphoSitePlus; P59808; - jPOST; P59808; - MaxQB; P59808; - PaxDb; P59808; - PRIDE; P59808; - DNASU; 70097; - GeneID; 70097; - KEGG; mmu:70097; - CTD; 23328; - MGI; MGI:1917347; Sash1 eggNOG; KOG4384; Eukaryota InParanoid; P59808; - KO; K23705; - OrthoDB; 949260at2759; - PhylomeDB; P59808; - BioGRID-ORCS; 70097; 0 hits in 19 CRISPR screens ChiTaRS; Sash1; mouse PRO; PR:P59808; - Proteomes; UP000000589; Unplaced RNAct; P59808; protein GO; GO:0005737; C:cytoplasm; ISO:MGI GO; GO:0016020; C:membrane; IDA:MGI GO; GO:0032991; C:protein-containing complex; ISO:MGI GO; GO:0001965; F:G-protein alpha-subunit binding; ISO:MGI GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; ISO:MGI GO; GO:0060090; F:molecular adaptor activity; ISO:MGI GO; GO:0008022; F:protein C-terminus binding; ISO:MGI GO; GO:0019901; F:protein kinase binding; ISO:MGI GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI GO; GO:0010595; P:positive regulation of endothelial cell migration; ISO:MGI GO; GO:0043507; P:positive regulation of JUN kinase activity; ISO:MGI GO; GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; ISO:MGI GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISO:MGI GO; GO:1900745; P:positive regulation of p38MAPK cascade; ISO:MGI GO; GO:0000209; P:protein polyubiquitination; ISO:MGI GO; GO:0010632; P:regulation of epithelial cell migration; ISO:MGI GO; GO:1902498; P:regulation of protein autoubiquitination; ISO:MGI GO; GO:1900044; P:regulation of protein K63-linked ubiquitination; ISO:MGI CDD; cd09559; SAM_SASH1_repeat1; 1 CDD; cd09492; SAM_SASH1_repeat2; 1 CDD; cd11967; SH3_SASH1; 1 Gene3D; 1.10.150.50; -; 2 InterPro; IPR021090; rSAM/SH3_domain-containing InterPro; IPR001660; SAM InterPro; IPR013761; SAM/pointed_sf InterPro; IPR037627; SASH1_SAM_repeat1 InterPro; IPR037630; SASH1_SAM_repeat2 InterPro; IPR035720; SASH1_SH3 InterPro; IPR036028; SH3-like_dom_sf InterPro; IPR001452; SH3_domain Pfam; PF00536; SAM_1; 1 Pfam; PF07647; SAM_2; 1 Pfam; PF07653; SH3_2; 1 Pfam; PF12485; SLY; 1 SMART; SM00454; SAM; 2 SMART; SM00326; SH3; 1 SUPFAM; SSF47769; SSF47769; 2 SUPFAM; SSF50044; SSF50044; 1 PROSITE; PS50105; SAM_DOMAIN; 2 PROSITE; PS50002; SH3; 1 1: Evidence at protein level; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; SH3 domain; Tumor suppressor CHAIN 1..1230 /note="SAM and SH3 domain-containing protein 1" /id="PRO_0000097598" DOMAIN 547..608 /note="SH3" /evidence="ECO:0000255|PROSITE-ProRule:PRU00192" DOMAIN 626..690 /note="SAM 1" /evidence="ECO:0000255|PROSITE-ProRule:PRU00184" DOMAIN 1160..1224 /note="SAM 2" /evidence="ECO:0000255|PROSITE-ProRule:PRU00184" REGION 844..852 /note="Required for interaction with TRAF6" /evidence="ECO:0000250|UniProtKB:O94885" COMPBIAS 972..1042 /note="Pro-rich" MOD_RES 83 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:19144319, ECO:0000244|PubMed:21183079" MOD_RES 241 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:21183079" MOD_RES 400 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:17242355, ECO:0000244|PubMed:21183079" MOD_RES 813 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:21183079" MOD_RES 831 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:19144319" SEQUENCE 1230 AA; 135591 MW; DDE421DB74FE49AF CRC64; MEEDAGAASP APEPEPEVDP ARELEPEAGV SESISRLWTD VMGILDGSLG NIDDLAQQYA DYYNTCFSDV CERMEELRKR RVSQDLDVEK PDASPTSLQL RSQIEESLGF CSAVSTPEVE RKYPLHKSNS EDGCVGKGDW KKKNKYFWQN FRKNQKGIMR QTSKGEDVGY VASEITMSDE ERIQLMMMVK EKMITIEEAL ARLKEYEAQH RQSSTLDPAD WPDGSYPTLD GSSTCNSREQ SDDETEDSVK FKRLHKLVNS TRRVRKKLIR VEEMKKPSAE GGEEHVFENS PVQDERSALY SGVHKKPFFY DGSPEKPPED DADSLTPSPS SSSLDTWGAG RKLVKTFSKG ESRGLIKPPK KMGTFFSYPE EEKAQKVSRS LTEGEMKKGL GSLSHGRTCS FGGFDLTNRS LHVGSNNSDP AGKEGDFVYK EVIKSPPAPR ISLGKKVRSV KETMRKRMSK KYSSPVSEQD SGLDGMPSSP ASGKPDSEHV DKPKLKAGGS VESLRSSLSG QSSMSGQTVS TTDSSTSNRE SVKSEDGDDE EPPYRGPFCG RARVHTDFTP SPYDTDSLKL KKGDIIDIIS KPPMGTWMGL LNNKVGTFKF IYVDVLNEEE EKPKRPTRRR KKGRPSQPKS VEDLLDRINL KEHMPTFLFN GYEDLDTFKL LEEEDLDELN IRDPEHRAVL LTAVELLQEY DSNSDQSGSQ EKLLVDNQGL SGRSPRDSGC YESSENLENA KTHKPSVLST KSSTESNLKS FTRSQPGNYP TLPLMKSGEV RKQGEEGRLG RGLAPDTAKS CDVPSVTDLS KNRRSLPVSI CRSCETLEGP EPVESWPRSH SLDDLQGDAD VGKNVPTEMP ETCSQNVPEV PQKTSACTSK ALPRGRDPTA DVMLLTQSKR FSDPPKTMAK KLDGSVVASN LGIAPPQCIP RDFEAQPPVK PGLTRTSLEG LRKGHDHHPL GTKEGVDGEQ SAPETRTQSR HPSQPPPVPA KKSRERLANG LHLVPSPEAP ILPLKKASPA SPVSPSDCPS PREPRPSSGT EPGSPACTRP PPWLAELPES TSLQEHGVKL GPVLSRKVSC VRGVDLEMLT ENKLQAEGID LTEEPYSDKH GRCGIPEALV QRYAEDLEQP ERDVATNMDQ IRVKLLRKQH RMAIPSGGLT EICRKPLSPG CVASMSDWLI SIGLPMYTST LSDAGFSTLS QVPSLSHSCL QEAGITEERH IRKLITAARL FKLPPSPEAM
Research Areas
Citations (0)

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Background

Sash1 may have a role in a signaling pathway. Could act as a tumor suppressor.

References

Trinidad, J.C., et al. Mol. Cell Proteomics 5(5):914-922(2006)Lindvall, J.M., et al. Cell. Immunol. 235(1):46-55(2005)Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)Okazaki, N., et al. DNA Res. 10(4):167-180(2003)Carninci, P., et al. Genome Res. 13 (6B), 1273-1289 (2003) :

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$ 277.78
Cat# BP19222b
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