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PSMD14 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O00487 |
|---|---|
| Clone Names | 100517123 |
| Gene ID | 10213 |
|---|---|
| Other Names | 26S proteasome non-ATPase regulatory subunit 14, 3419-, 26S proteasome regulatory subunit RPN11, 26S proteasome-associated PAD1 homolog 1, PSMD14, POH1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PSMD14 |
|---|---|
| Synonyms | POH1 |
| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. |
| Tissue Location | Widely expressed. Highest levels in heart and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PSMD14 is a component of the 26S proteasome, amultiprotein complex that degrades proteins targeted fordestruction by the ubiquitin pathway (Spataro et al., 1997 [PubMed9374539]).
References
Byrne, A., et al. Exp. Cell Res. 316(2):258-271(2010)Ma, Z., et al. Pediatr Int 51(5):732-735(2009)Cooper, E.M., et al. EMBO J. 28(6):621-631(2009)Koulich, E., et al. Mol. Biol. Cell 19(3):1072-1082(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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