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MSX1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P28360 |
|---|---|
| Clone Names | 100617159 |
| Gene ID | 4487 |
|---|---|
| Other Names | Homeobox protein MSX-1, Homeobox protein Hox-7, Msh homeobox 1-like protein, MSX1, HOX7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MSX1 (HGNC:7391) |
|---|---|
| Function | Acts as a transcriptional repressor (By similarity). Capable of transcription autoinactivation (By similarity). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (By similarity). Represses transcription of myoblast differentiation factors (By similarity). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (By similarity). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (By similarity). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (By similarity). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (By similarity). Required for BMP4 expression in dental mesenchyme cells (By similarity). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (By similarity). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (By similarity). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (By similarity). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle (By similarity). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (By similarity). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (By similarity). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (By similarity). Required for correct formation and thickness of the nail plate (By similarity). May play a role in limb-pattern formation (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P13297}. Note=Interaction with PIAS1 is required for localization to the nuclear periphery (By similarity). {ECO:0000250|UniProtKB:P13297} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the muscle segment homeoboxgene family. The encoded protein functions as a transcriptionalrepressor during embryogenesis through interactions with componentsof the core transcription complex and other homeoproteins. It mayalso have roles in limb-pattern formation, craniofacialdevelopment, particularly odontogenesis, and tumor growthinhibition. Mutations in this gene, which was once known ashomeobox 7, have been associated with nonsyndromic cleft lip withor without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome,and autosomoal dominant hypodontia.
References
Sliwinski, T., et al. Cancer Epidemiol 34(5):652-655(2010)Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Suazo, J., et al. Am. J. Med. Genet. A 152A (8), 2011-2016 (2010) :Doi, T., et al. J. Pediatr. Surg. 45(6):1187-1191(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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