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GPR109B Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P49019 |
|---|---|
| Clone Names | 110826171 |
| Gene ID | 8843 |
|---|---|
| Other Names | Hydroxycarboxylic acid receptor 3, G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, Niacin receptor 2, Nicotinic acid receptor 2, HCAR3, GPR109B, HCA3, HM74B, NIACR2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HCAR3 |
|---|---|
| Synonyms | GPR109B, HCA3, HM74B, NIACR2 |
| Function | Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta- oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expression largely restricted to adipose tissue and spleen. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Mandrika, I., et al. Biochem. Biophys. Res. Commun. 395(2):281-287(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Jeninga, E.H., et al. J. Biol. Chem. 284(39):26385-26393(2009)Ahmed, K., et al. J. Biol. Chem. 284(33):21928-21933(2009)
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