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MIXL1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H2W2
Clone Names 100517259
Additional Information
Gene ID 83881
Other Names Homeobox protein MIXL1, Homeodomain protein MIX, hMix, MIX1 homeobox-like protein 1, Mix1 homeobox-like protein, MIXL1, MIXL
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MIXL1
Synonyms MIXL
Function Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12070013, ECO:0000269|PubMed:17303500}
Tissue Location Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to immature B- and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level).
Research Areas
Citations (0)
citation

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Background

Homeodomain proteins, such as MIXL1, are transcriptionfactors that regulate cell fate during development (Hart et al.,2005 [PubMed 15982639]).

References

Davis, R.P., et al. Blood 111(4):1876-1884(2008)Drakos, E., et al. Hum. Pathol. 38(3):500-507(2007)Hart, A.H., et al. Biochem. Biophys. Res. Commun. 333(4):1361-1369(2005)Guo, W., et al. Blood 100(1):89-95(2002)Sahr, K., et al. Gene 291 (1-2), 135-147 (2002) :

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$ 277.78
Cat# BP19284c
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