MIXL1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H2W2 |
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Clone Names | 100517259 |
Gene ID | 83881 |
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Other Names | Homeobox protein MIXL1, Homeodomain protein MIX, hMix, MIX1 homeobox-like protein 1, Mix1 homeobox-like protein, MIXL1, MIXL |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MIXL1 |
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Synonyms | MIXL |
Function | Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12070013, ECO:0000269|PubMed:17303500} |
Tissue Location | Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to immature B- and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Homeodomain proteins, such as MIXL1, are transcriptionfactors that regulate cell fate during development (Hart et al.,2005 [PubMed 15982639]).
References
Davis, R.P., et al. Blood 111(4):1876-1884(2008)Drakos, E., et al. Hum. Pathol. 38(3):500-507(2007)Hart, A.H., et al. Biochem. Biophys. Res. Commun. 333(4):1361-1369(2005)Guo, W., et al. Blood 100(1):89-95(2002)Sahr, K., et al. Gene 291 (1-2), 135-147 (2002) :
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