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ENTPD5 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75356 |
|---|---|
| Clone Names | 100324155 |
| Gene ID | 957 |
|---|---|
| Other Names | Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, Nucleoside diphosphatase, Uridine-diphosphatase ENTPD5, UDPase ENTPD5, ENTPD5, CD39L4, PCPH |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ENTPD5 (HGNC:3367) |
|---|---|
| Function | Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:10400613, PubMed:15698960). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP- glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity). |
| Cellular Location | Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9WUZ9}. Secreted |
| Tissue Location | Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is similar to E-typenucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such asCD39, mediate catabolism of extracellular nucleotides. ENTPD5contains 4 apyrase-conserved regions which is characteristic ofNTPases.
References
Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)Villar, J., et al. Cancer Res. 69(1):102-110(2009)Villar, J., et al. Cancer Res. 67(22):10859-10868(2007)Regadera, J., et al. Int. J. Oncol. 28(3):595-604(2006)Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
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