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Mouse Derl2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8BNI4
Clone Names 110919069
Additional Information
Gene ID 116891
Other Names Derlin-2, Degradation in endoplasmic reticulum protein 2, Der1-like protein 2, F-LANa, Derl2, Der2, Flana
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Derl2 {ECO:0000312|MGI:MGI:2151483}
Function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9GZP9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9GZP9}
Tissue Location Widely expressed, with lowest levels in brain and heart.
Research Areas
Citations (0)

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Background

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity).

References

Schaheen, B., et al. J. Cell. Sci. 122 (PT 13), 2228-2239 (2009) :Oda, Y., et al. J. Cell Biol. 172(3):383-393(2006)Lilley, B.N., et al. Proc. Natl. Acad. Sci. U.S.A. 102(40):14296-14301(2005)Kaput, J., et al. Physiol. Genomics 18(3):316-324(2004)Lilley, B.N., et al. Nature 429(6994):834-840(2004)

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$ 277.78
Cat# BP19315b
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